Archived: 13th Winter Conference
on Medicinal & Bioorganic Chemistry

Detecting Circulating Tumor Cells in Clinical Trials – Making Circulating Tumor Cells Glow using a Telomerase-based Assay

Accelerating Clinical Trials using NGS Liquid Biopsy

Using ctDNA Biomarkers in Ignyta’s Clinical Trials: Detecting Activating Alterations, Monitoring Drug Efficacy, and Detecting Resistance Mechanisms

Bringing Exosome Liquid Biopsy Technology into the Realm of Routine Clinical Use

Cell Free DNA Analysis of NSCLC Patients as a Paradigm for Clinical use of Liquid Biopsies

Cutting-Edge PET Radiochemistry Methodologies Applied to Drug Development

Enabling Late Stage Fluorination Methods for the Discovery and Radiosynthesis of PET Imaging Agents

Development of PET Imaging Tracers for Neuroscience Applications

Empowering Preclinical PET Imaging: Facile and User-Friendly 18F-labeling of Complex Molecules

Converting a Medicinal Chemistry Synthesis into a Manufacturing Process

C-H Functionalization Methods as Cutting-Edge Synthesis Tools for Medicinal Chemists

Hydrophosphinations of Strained Rings

Recent Forays in Methods Development and Complex Molecule Synthesis

Target ID Successes and Lessons

Computational Approaches to Target ID Using Large Scale Protein-Ligand Modeling

A Chemoproteomic Approach to Identify Drivers of BACE1 Inhibitor Ocular Toxicity

The Splice is Right: Phenotypic Drug Discovery and Target ID for Spinal Muscular Atrophy

Light-controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes

Tracking Drug Action by Chemical Proteomics

Principles and Applications of DNA-Encoded Library Technologies

Biophysical and Chemical Methods to Interrogate Drug-Target Engagement

Merck Drug Discovery Enabled

Structure-based drug design with G protein-coupled receptors: The discovery of Highly Selective M1 Agonists

Accounting for Lysosomotropism as a Strategy for Prioritizing Selective Inhibitors of BACE

The Discovery of a New Generation of Potent and Selective PI3Kδ Inhibitors

Chemically Non-Reactive Glycine Sulfonamide Inhibitors of Diacylglycerol Lipase

Modern Chemistry: Tools to Enable the Practicing Chemist

Preparation and Biological Evaluation of trans-Cyclopropyl-linked BACE1 Inhibitors

Invention of Grazoprevir, a Hepatitis C NS3 Protease Inhibitor

Inhibition of the HCV Polymerase NS5B as a Means Towards Curative Therapy

The Discovery of HCV NS5A Replication Complex Inhibitors

Hepatitis B: Is There a Path to a Cure?

What will it take to Eradicate HIV: A Drug Discovery Perspective

Tackling a Pandemic Disease: A History of HIV Drug Discovery at Merck