16th Winter Conference
on Medicinal & Bioorganic Chemistry

Mapping Chemical Space via High-throughput Experimentation: New Tools, New Reactions, and New Bicyclic Scaffolds

New Strategies for Redox Catalysis

Enabling and Accelerating Drug Discovery with High Throughput Chemistry

Towards Picomole Library Synthesis and Analysis using Acoustic Technologies

Discovery of Small Molecule Inhibitors Using a Modern Screening Paradigm and High Throughput Chemistry

Discovery and Development of Nirmatrelvir

Developing Large-Scale Syntheses of Molnupiravir, an Antiviral for COVID-19

The Antiviral Program for Pandemics at NCATS-NIH

Expanding the potential of RNA beyond Covid-19

Advancing Chemical Biology through Innovative Synthesis

Reactive Fragments in Covalent Drug Discovery

Assigning Functionality to Cysteines by Base Editing of Cancer Dependency Genes

Enhancing the Scope of Ligandability with Diverse Electrophiles

Redox Activation Strategies to Profile Biological Systems

Discovery of MK-6158 an oral, once daily, Soluble Guanylate Cyclase (sGC) Stimulator for the treatment of Pulmonary Arterial Hypertension

Discovery of Selective, CNS-Penetrant Covalent Inhibitors of Bruton’s Tyrosine Kinase for the Treatment of Multiple Sclerosis

Choose Your Own Adventure in Metal-Hydride Catalysis

The Development of Asymmetric Organocatalysis and Metallaphotoredox

Discovery of bRo5 Drugs: Lessons from the Past and Progress toward Better Prediction of Oral Absorption

The Discovery and Characterization of CFT-18442: A Potent, Selective, and Orally Bioavailable Degrader of BRAF V600E

Rational Discovery of BRD4 Monovalent Protein-Degraders

Discovery of RG6006, a Tethered Macrocyclic Peptide Targeting Acinetobacter baumannii

The Discovery and Development of Lenacapavir (GS-6207): a Twice-Yearly Injectable or Orally Dosed First-in-Class HIV Capsid Inhibitor

Natural Product Drug Discovery in the Age of Metabolomics and Machine Learning

Harnessing Human Milk Oligosaccharides to Combat Group B Streptococcus

Human Kinase Inhibitors as Starting Points for Kinetoplastid Drug Discovery

Discovery of JNJ-64264681: A Potent and Selective Covalent BTK Inhibitor for Treating Hematological Malignancies

Synthesis of MC4R Antagonist PF-07258669: From First Synthesis to Development of Scalable Route for Clinical Studies

Discovery of a Renal Outer Medullary Potassium (ROMK) Channel Inhibitor Clinical Candidate for the Treatment of Heart Failure

Discovery and Profiling of a Peripherally-restricted GABA-A Positive Allosteric Modulator for Treatment of Irritable Bowel Syndrome

Invention of the Dual Plasmepsin IX/X Inhibitor MK-7602 — A Promising Next Generation Antimalarial Agent from an Efficient Academic/Industrial Collaboration

The Discovery of KIN-2787, A Solution to the Challenges of Pan-RAF Kinase Inhibition

Conquest of a PPI Everest: Disrupting the YAP/TEAD Interface with Small Molecules

Phenotypic Discovery and Optimization of Potent T-Cell Modulators: Dual Inhibition of Diacylglycerol Kinases α and ζ