16th Winter Conference
on Medicinal & Bioorganic Chemistry
January 29th - February 2nd 2023
Steamboat Springs Resort, Colorado
Agenda
Sunday, January 29th 2023
Drug Hunting
Program Chair: Klemens Hoegenauer, Novartis
Is it Time for Computation-driven Drug Design? The Discovery of a Small Molecule STING Agonist using the QUAISAR Computational Platform
Medicinal Chemistry with the Fifth Element: Discovery of Arginase Inhibitor AZD0011
Discovery of DGAT2 Inhibitors for the Treatment of NASH
Drug Hunter Award:
CGRP Receptor Antagonists for the Treatment of Migraine
Networking Session
Welcome Reception

Monday, January 30th 2023
Enabling Methodology and Technology
Program Chair: Iulia Strambeanu, Janssen
Mapping Chemical Space via High-throughput Experimentation: New Tools, New Reactions, and New Bicyclic Scaffolds
New Strategies for Redox Catalysis
Enabling and Accelerating Drug Discovery with High Throughput Chemistry
Towards Picomole Library Synthesis and Analysis using Acoustic Technologies
Discovery of Small Molecule Inhibitors Using a Modern Screening Paradigm and High Throughput Chemistry
Antivirals and Pandemic Diseases, Past, Present and Future
Program Chair: John McCauley, Merck
Discovery and Development of Nirmatrelvir
Developing Large-Scale Syntheses of Molnupiravir, an Antiviral for COVID-19
The Antiviral Program for Pandemics at NCATS-NIH
Expanding the potential of RNA beyond Covid-19
Tuesday, January 31st 2023
SynthChemBio
Program Chair: Niyi Fadeyi, InduPro
Advancing Chemical Biology through Innovative Synthesis
Reactive Fragments in Covalent Drug Discovery
Assigning Functionality to Cysteines by Base Editing of Cancer Dependency Genes
Enhancing the Scope of Ligandability with Diverse Electrophiles
Redox Activation Strategies to Profile Biological Systems
MacMillan Alumni Session: Topics in Medicinal and Synthetic Chemistry
Program Chair: Mike VanHeyst, GSK
Discovery of MK-6158 an oral, once daily, Soluble Guanylate Cyclase (sGC) Stimulator for the treatment of Pulmonary Arterial Hypertension
Discovery of Selective, CNS-Penetrant Covalent Inhibitors of Bruton’s Tyrosine Kinase for the Treatment of Multiple Sclerosis
Choose Your Own Adventure in Metal-Hydride Catalysis
Robert M. Williams' Memorial KEYNOTE LECTURE
Program Chair: Mike VanHeyst, GSK
The Development of Asymmetric Organocatalysis and Metallaphotoredox
Networking Session
Robert M. Williams' Memorial RECEPTION

Wednesday, February 1st 2023
Beyond Ro5 and Novel Modalities
Program Chair: Lou Chupak, Bristol Myers Squibb
Discovery of bRo5 Drugs: Lessons from the Past and Progress toward Better Prediction of Oral Absorption
The Discovery and Characterization of CFT-18442: A Potent, Selective, and Orally Bioavailable Degrader of BRAF V600E
Rational Discovery of BRD4 Monovalent Protein-Degraders
Discovery of RG6006, a Tethered Macrocyclic Peptide Targeting Acinetobacter baumannii
The Discovery and Development of Lenacapavir (GS-6207): a Twice-Yearly Injectable or Orally Dosed First-in-Class HIV Capsid Inhibitor
General Session: Synthesis and Med Chem
Program Chair: Amy Dounay, Colorado College
Natural Product Drug Discovery in the Age of Metabolomics and Machine Learning
Harnessing Human Milk Oligosaccharides to Combat Group B Streptococcus
Human Kinase Inhibitors as Starting Points for Kinetoplastid Drug Discovery
Discovery of JNJ-64264681: A Potent and Selective Covalent BTK Inhibitor for Treating Hematological Malignancies
Synthesis of MC4R Antagonist PF-07258669: From First Synthesis to Development of Scalable Route for Clinical Studies
Discovery of a Renal Outer Medullary Potassium (ROMK) Channel Inhibitor Clinical Candidate for the Treatment of Heart Failure
Networking Session
POSTER SESSION

Thursday, February 2nd 2023
Late Breaking Stories and 1st Disclosures
Program Chair: Dr Hanna Wisniewska, Pfizer
Discovery and Profiling of a Peripherally-restricted GABA-A Positive Allosteric Modulator for Treatment of Irritable Bowel Syndrome
Invention of the Dual Plasmepsin IX/X Inhibitor MK-7602 — A Promising Next Generation Antimalarial Agent from an Efficient Academic/Industrial Collaboration
The Discovery of KIN-2787, A Solution to the Challenges of Pan-RAF Kinase Inhibition
Conquest of a PPI Everest: Disrupting the YAP/TEAD Interface with Small Molecules
Phenotypic Discovery and Optimization of Potent T-Cell Modulators: Dual Inhibition of Diacylglycerol Kinases α and ζ
Networking Session
Conference Dinner - Top of the Gondola

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