Archived: 9th Winter Conference
on Medicinal & Bioorganic Chemistry

PK/PD Modeling and Simulation – Fundamentals and Applications to Drug Development

PK/PD Modeling in Candidate Selection and Early Development

Application of Imaging in Translational Drug Discovery and Development

An Animal to Human Translational PK-PD Approach Based on Brain Receptor Occupancy To Establish Clinical Dose

Overview of the Field, Challenges and Opportunities

US FAAH Inhibitors for the Treatment of Pain

Molecular Mechanisms of Acquired Resistance to Kinase Inhibitors

Synthesis and Activity of 1-(3-amino-2-hydroxy-1-phenylpropyl)Indolin-2-ones and Derivatives: Discovery of Selective Norepinephrine Reuptake Inhibitor WAY-318068

CGRP Receptor Antagonists as Novel Pain Therapeutics

Identification of a Systemically Active Peptidic Kappa Opioid Receptor Antagonist and its Potential Applications

Old Drugs for New Targets: A Case Study with Novobiocin and Hsp90

Synthetic Mimics of Mammalian Cell Surface Receptors: New Tools for Drug Delivery and Probes of Cellular Biology

Utilizing Nature as a Source of New Probes for CNS Disorders

Towards the Synthesis of Selective CDK7 Inhibitors as Potential Anti-Cancer Drugs

Design of Orally Active and Highly Specific Matrix Metalloproteinase-13 Inhibitors for the Treatment of Osteoarthritis

Discovery of Potent Measles Virus RNA-Dependent RNA Polymerase Inhibitors

Discovery of Developmental Pathway Inhibitors: A Case Study for Hedgehog Pathway Modulators

The Discovery of Novel Inhibitors of 11b-Hydroxysteroid Dehydrogenase Type 1 (11b-HSD1)

Hydroxamate Based Histone Deacetylase Inhibitors with Improved Potency and Reduced Affinity for the hERG Ion Channel

Predicting and Controlling BCR-ABL Mutation-Mediated Resistance in CML: Cornering an Escape Artist

Oncogenic Tyrosine Kinases Modulate Genomic Stability and Apoptosis to Resist Their inhibitors and Promote Malignant Disease Progression

New Mechanisms of Antibiotic Resistance, and Reversing Resistance with Small Molecules

Notre Dame Resistance to beta-Lactam Antibiotics in Methicillin-Resistant Staphylococcus Aureus (MRSA)

Not Itemized

Glutamate Receptor Agonist/Antagonists

Total Synthesis and Analog Development of Oximidine II: Discovery of an Unprecedented Reductive Castro-Stephens Tandem Reaction

Modular Approach to Compound Libraries Inspired by Martinellic Acid and the Steroid Nuclear Hormones

Pyrazolopyrimidines as ATP Competitive, Highly Potent and Selective MTOR Inhibitors for Oncology

Novel Opioid Receptor Probes Derived From Structural Modification to the Neo-Clerodane Diterpene