Archived: 2nd Winter Conference
on Medicinal & Bioorganic Chemistry

January 26th - 31st 1997

Steamboat Springs Resort, Colorado


Sunday, January 26th 1997

Asymmetric Catalysis inorganic Synthesis

Program Chair: Victor Snieckus, University of Waterloo

Victor Snieckus University of Waterloo

Overview: Catalysis in Asymmetric Synthesis

Stephen Buchwald Massachusetts Institute of Technology (MIT

Development and Use of Transition Metal Catalysis and Reagents in Organic Synthesis

Monday, January 27th 1997

Asymmetric Catalysis in Organic Synthesis (cont.)

Program Chair: Victor Snieckus, University of Waterloo

Andreas Pfaltz Max Planck Institut-Muelheim

Chiral Oxazolines as Ligands in Asymmetric Catalysts

Tomas Hudlicky University of Florida

Selective Enzymatic and Electrochemical Methods of Oxidation and Reduction. Specificity and Synthetic Utility.

Dennis Riley University of Monsanto

Synthesis and Design of Synthesis Enzymes: Mn(II) Pentaaza Macrocyclic Ligand Complexes as Superoxide Dismutase Mimics and their Utility as Therapeutics

Kim D. Janda Scripps Institute

Controlling Chemical Reactivity Using Unnatural Catalysts

Synthesis on Solid Support

Program Chair: Anthony G.M. Barrett, Imperial College

David Rees Organon

Solid-Phase Organic Synthesis: and Introduction and Overview

Robert Armstrong University of California, Los Angeles (UCLA)

Reaction and Structure Templated in Sloid Support Synthesis

Steven Ley University of Cambridge

Development of Synthesis Methods Suitable for Applications in Combinatorial Chemistry

Tuesday, January 28th 1997

Synthesis on Solid Support (cont.)

Program Chair: Anthony G.M. Barrett, Imperial College

Mark Kurth University of California, Davis (UC-Davis)

Constructing Organic Compounds on Solid Phase

Jack Hodges Parke-Davis

New Solid-Supported Reagents and their Utilities

Milind Deshpande Bristol-Myers Squibb

New Methods in Solid Phase Synthesis

Combinatorial Chemistry: Update and Appraisal

Program Chair: Eric M. Gordon, Versicor

Eric M. Gordon Versicor

Introduction to Combinatorial Chemistry

Paul Bartlett University of California, Berkeley

Interfacing Structure-Based Design and Combinatorial Chemistry

David Brown Glaxo Wellcome

Pathways for the Development of Combinatorial Technologies

John J. Baldwin Pharmacopeia

Strategies for Lead Discove5ry: Synthesis and Evaluation of N-coded Synthetic Combinatorial Libraries

Daniel L. Veber SKB

Resin Chemistries and Bead Technologied for Use in Combinatorial Chemistry and Lead Discovery

Wednesday, January 29th 1997

KEYNOTE | “Exploring Biological Catalysis”

Program Chair: Stephen Benkovic, Penn State University

General Oral Papers

Not Itemized

Thursday, January 30th 1997

Molecular Recognition in Drug Design

Program Chair: Patrick Y. Lam, DuPont Merck

Patrick Y. Lam DuPont Merck

Molecular Recognition in Drug Design: Overview and Selected Examples

Andrew Hamilton University of Pittsburgh

Molecular Recognition in Organic and Biological Chemistry

Dennis A. Dougherty Caltech

Caption-pi Interactions in Chemistry and Molecular Neurobiology

Dudley H. Williams University of Cambridge

New Twists in the Killing of Super Bugs

Ralph F. Hirschmann University of Pennsylvania

Peptide Related Research: A Means to Chemical and Biological Understanding

Tomi K. Sawyer Parke-Davis

Src SH2 Structure-based Drug Design

Steven L. Bender Agouron

Caption-pi Interactions in Structure-based Design of Potent and Selective Inhibitors of Matrix Metalloproteinases

Friday, January 31st 1997

Drug Delivery: Problems and Strategies

Program Chair: Valentino Stella, University of Kansas / Michael D. Taylor, Parke-Davis

Valentino Stella University of Kansas
  1. Overview: Barriers to Efficient Drug Delivery
  2. Delivery of Sparingly Soluble Drugs
Ronald Borchardt University of Kansas

Membrane Transport as a Barrier to Drug Delivery

Rick Morrison Bristol- Myers Squibb

Predicting Human Bioavailability and Pharmacokinetics from Preclinical Data

Michael D. Taylor Parke-Daivs

Overview: Delivery Strategies and Drug Design

Bruce Aungst DuPont-Merck

Formulation, Prodrug and Analog Approaches to Improving Oral Bioavailability

Dhirin Thakker University of North Carolina

Prodrug Strategies for Enhanced and Targeted Delivery of Therapeutic Agents

Ronald Haak Alza

Recent Advances in Transdermal (and/or Oral Controlled Releases) Technologies

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