Archived: 14th Winter Conference
on Medicinal & Bioorganic Chemistry

Novel STING Agonists for Immuno-oncology

Discovery of BMS-986158, an Oral BET Inhibitor

Targeting the Adenosine Pathway with Non-Nucleoside Inhibitors of CD73

Design of Selective, Heme-binding Inhibitors of Tryptophan-2,3-dioxygenase (TDO)

Giving Med Chemists the Comp Chem Tools for What They Want and What They Need

Computational Methods Help Find Chemical Matter to Uncover Novel Biology

The Role of Water Molecule in Ketohexokinase Inhibitor Design

Impact of Computational Chemistry Post Candidate Selection and Translating Lessons Learned back into Discovery

Reimagining Druggability using Chemoproteomic Platforms

Mapping Binding Site Hotspots in the Global Proteome by Photo-affinity Labeling Mass Spectrometry

Chemical Biology to provide insight into Small Molecule Targeting of BCL6

Targeted Protein Degradation

Overview of Current Therapies for the Treatment of Pain

Breathe Easy: Mechanistic Insights Enable a Path Forward for Highly Selective Nav1.7 Inhibitors

Harnessing Opioid Receptor Signaling to Improve Pain Therapeutics

Discovery And Optimization Of A Novel CGRP Receptor Antagonist Chemotype For The Treatment of Migraine

TRPA1: A Pain Target or a Painful Target?

Structure-Based Drug Discovery in the Search for Nav1.7 Inhibitors

Complexities of Targeting Autophagy to Treat Human Disease

Targeting the Autophagy-Initiating Kinase ULK1

Combined Targeting of MAP Kinase Signalling and Autophagy for the Future Therapy of Cancers Driven by the RAS Pathway

Advances in Targeting Lysosomotrophic Agents

Discovery and Evaluation of Non-Nitrocatechol COMT Inhibitors for Treatment of Psychiatric Conditions

Intrinsic Aminomethyl Pyridine Enables Regioselective C-H Arylation in the Synthesis of IKur Inhibitor, BMS-919373

Development of Inhibitors of MsbA: From HTS to Gram-negative Wild-type Activity

Hit-to-lead Medicinal Chemistry Targeting Neglected Tropical Diseases

Targeting of the Glutamine Antagonist DON (6-Diazo-5-oxo-L-norleucine) via Prodrug Approach

The Role of Solution Conformation in Structure-Guided Fragment Optimization

Pyridyl Urea Sulfonamide Inhibitors of NaV1.7: Intramolecular Hydrogen Bonding Leads to Improved Properties and Exposure

New Broad Scope Strategies for Amine Synthesis

Recent Advances in the Remote Functionalization of Aliphatic C-H Bonds via Decatungstate Photocatalysis

Enablement of Photoredox Csp2-Csp3 Cross Coupling Reactions

Scaling Catalytic Photochemistry with Lasers

Photoredox Catalysis – An Enabling Platform for Discovery and Development

Controlling Catalysis with Visible Light

Translational Chemistry