Archived: 12th Winter Conference
on Medicinal & Bioorganic Chemistry

Leveraging Emerging C-H Functionalization Chemistries for Efficient Diversification of Medicinally Important Heterocycles

Novel Methods for Synthesis and C-H Functionalization of Arenes and Heteroarenes

Cu(I)-Catalyzed Arene Functionalization via 1,3-Halogen Migration

Recent Developments in the Sulfination of (Hetero) Aromatic Rings: Direct Access to Sulfones and Sulfonamides of Medicinal Chemistry Relevance.

Cascade Polyketide and Polyene Cyclizations: Biomimetic Total Synthesis of Hongoquercin B

Route Development for the Synthesis of EML4-ALK Inhibitor PF-06463922

Lipo-Peptide Glycoconjugates for Targeting Antigen Presenting Cells

Identification of GLP-1 Secretagogues – Targeting Type 2 Diabetes Mellitus

Targeting PI3Kd for Inflammation: Discovery and In Vivo Evaluation AMG319 and Related Inhibitors

Hit‐to‐lead Medicinal Chemistry for African Sleeping Sickness: An Invitation to Shared Hit‐to‐Lead Medicinal Chemistry Pursuit of Chemotypes Identified from a Kinase‐Targeted High‐Throughput Screening Campaign.

Mechanism Based Translational Biomarkers for the Prediction of Drug Induced Liver Injury

Reactive Metabolites in Drug-Induced Liver Injury

Inhibition of Hepatobiliary Transporters in Drug-Induced Liver Injury

A Chemoproteomic Platform for Profiling the Targets of Reactive Drug Metabolites

Histone Methyltransferase Inhibitors: Fast acting Molecules against Blood and Liver Stage Malaria Parasites

Dendritic Vaccine Delivery Systems

Application of PET and SPECT Radiotracers in Drug Development

Drug Discovery Efforts towards the Identification of Potent and Selective Tankyrase Inhibitors

Drug Discovery and Development by Design: Using the Knowledge from every Organic Crystal Structure Ever Published

Development of a Novel Class of Small Molecules used to Potentiate Tumor-Specific Oncolytic Virus Infection

Novel Chemical Probes for Use in the Study of Peptidoglycan Biosynthesis

Tetrazolone as an Acid Bioisostere: ‘Clickable’ Synthesis & Applications to Marketed Drugs

Monitoring Target Engagement and Signaling Pathways through Chemoproteomic Interrogation of Nucleotide Binding Space

Monitoring Target Engagement using the Cellular Thermal Shift Assay for Lead Drug Development, Drug Deorphanization and Off-Target Studies

Simultaneous Analysis of Cancer Pathway Deregulation (Tumor-Centric) and Cancer Immune Response (Host-Centric)

Understanding and Overcoming the Vagaries of Target Engagement within the Ras-RAF-MEK-ERK Signalling Pathway

ALIS Affinity Selection in Pharmaceutical Discovery

Discovery of a Novel Mechanism for the Regulation of Apolipoprotein E

Application of Encoded Library Technology (ELT): From Library Design to the Clinic

Discovery and Development of Irreversible Inhibitors Targeting the Serine-hydrolase Superfamily

H2L 2020

Integrating Design, Analysis, and Visualization into the Phenotoypic Drug Discovery Workflow

From Old Targets to New, The Power of FBLG to Generate Novel Chemical Equity for Important Drug Targets

Discovery of Novel PDE10 Inhibitors for the Treatment of Schizophrenia Enabled by Parallel Hit-to-Lead Efforts

Activity-Based Proteomics – Applications for Enzyme and Inhibitor Discovery