Archived: 11th Winter Conference
on Medicinal & Bioorganic Chemistry

Targeting Metabolic Reprogramming for Cancer

New Strategies for Impacting Glutamine Metabolism in Cancer Cells

Pyruvate Kinase M2 Activators Induce Tetramerization and Reduce Tumor Size in Mouse Xenograft Models

Discovery and Characterization of Mutant IDH Inhibitors for the Treatment of Cancer

Structure-based Identification of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors

Design of Optimized Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors

The Discovery, Optimisation, and Mode of Action of Spiroindolone Antimalarials

The Discovery and Optimization of Novel Anti-Malarial Agents Derived from Phenotypic Screening

Rational Design of Antibiotics for Tuberculosis that Target Biotin Metabolism

Syntheses and Evaluation of New Anti-tuberculosis Agents Inspired by Studies of Mycobacterial Iron Assimilation

Challenges in Glycan Synthesis

The Quest for Affordable, Fully Synthetic Artemisinin

Chemical Biotechnology Applied to Endocrine Hormones

Chemoselective Enrichment for Natural Products Discovery

Structural Insights into Targeted Drug Delivery via the Human Folate Receptors

Base Metal Catalysis for Organic Synthesis

Inhibitors of 5-HT2CR Protein:Protein Interactions for Stimulant Pharmacotherapy

Facilitation of Scale-Up of Novel Oncology Candidates through Early Route Optimisation – Risk and Rewards

Advances in Ni- and Fe-Catalyzed Cycloaddition Chemistry

Covalent Inhibitors in Drug Design

Recent Advances in siRNA Delivery

The Impact of Oxetane and Bicyclo[1.1.1]pentane Motifs on Biopharmaceutical Properties

Drug Discovery and Optimization using Computer Generated Molecules with Predicted Potencies

Phenotypic Drug Discovery of Novel Anti-Angiogenics

Studies Leading to the Clinical Candidate EPZ-5676, a DOT1L Inhibitor for the Treatment of MLL-rearranged Leukemia

Discovery of a Series of Brain-Penetrant Kynurenine Aminotransferase II Inhibitors for the Treatment of Schizophrenia

Discovery of HCV Polymerase Inhibitors ABT-333 and ABT-072: Components of an IFN-sparing Drug Regimen

Development and Application of a Highly Selective Histone Deacetylase 8 Inhibitor

Imagine: Pharma Be Fractal

Discovery of HCV NS5A Replication Complex Inhibitors

Optimization of HCV NS5B Thumb Site II Inhibitors for Use in Interferon-Free Regimens

Discovery of a Novel Allosteric Mechanism for the Regulation of HCV NS3 Protein using Fragment Screening and Structure-Based Design

The Discovery of a Potent and Selective Irreversible HCV Protease Inhibitor

DGAT1 Inhibitors for Suppression of Postprandial Triglycerides

The Discovery and Development of Anacetrapib, a Potent and Orally Active CETP Inhibitor

The Discovery and Optimization of a Novel Series of LPA Receptor Antagonists with Efficacy in Multiple Mouse Models of Fibrosis

Development of a Potent, Selective, and Orally Bioavailable mPGES-1 Inhibitor based on a Benzoxazole Template for the Treatment of Osteoarthritis Pain and Inflammation