Archived: 10th Winter Conference
on Medicinal & Bioorganic Chemistry

Time Dependent Inactivation of Cytochrome P450: Mechanisms, Kinetics and Consequences

Experimental Assessment of Time Dependent Inhibition in Drug Discovery: Practical Considerations

Time Dependent Inhibition of Cytochrome P450: Implications in Drug Discovery

Identification of Reaction Pathways Associated with Mechanism-Based Inhibition of Cytochrome P450 3A4

Approaches to Therapeutics for Huntington’s Disease

Structure and Property Guided Discovery of Highly Efficacious Small Molecule Beta-secretase Inhibitors for Alzheimer’s Disease

Potential Therapeutic treatment for Huntington’s Disease

Refolding Misfolded Proteins for the Discovery of New Therapeutics to Treat ALS

Catalytic Transformations of Arenes

Harnessing High-Throughput Experimentation for Catalytic Reaction Development at Merck

Impact of Enzymatic Catalysis on Asymmetric Total Synthesis of natural Products and Pharmaceuticals: Dioxygenations, Reductions and N-demethylations

ChiPros®-Optically Active Intermediates on an Industrial Scale

Welcome / Introduction

beta-Secretase Inhibitors for the Treatment of Alzheimer’s Disease: A Novel Class of Spirocyclic Sulfamides

Catechol-O-methyltransferase (COMT) Inhibitors for the Treatment of Cognitive Impairment in Schizophrenia

Discovery of Prolyl 4-Hydroxylase Inhibitors that are Potent Oral Erythropoietin Secretagogues

The Discovery of Novel Gamma-Secretase Modulators for the Treatment of Alzheimer’s Disease

Discovery and Lead Optimization of Benzotriazole Series of mGlur2 Positive Allosteric Modulators for the Treatment of Schizophrenia.

Application of Parallel Medicinal Chemistry Methods for the Rapid and Efficient Optimization of Hits-to-Leads-to-Clinical Candidates

The Synthesis and Evaluation of BS-194: a potent, oral bioavailable CDK-Inhibitor

Studies of Marine Cytotoxins – Total Synthesis of Peloruside B

INX-08189 A Novel Double Pro-Drug and Clinical Candidate for Hepatitis C Virus

The Evolution of Cancer Drug Discovery: From the Cytotoxic Paradigm to the Targeted Therapeutics, What Lessons Have We Learned?

Discovery of the Next Generation HIV Integrase Inhibitor S/GSK1349572

The LEDGINs: First in Class Antiviral Targeting the LEDGF/p75-IN Interaction

Inhibitors of Hepatitis C Virus

Discovery of BILB1941, a Non-Nucleoside NS5B Polmerase Inhibitor for the Treatment of Hepatitis C Virus Infection

2’-α-F, 2’-β-C-Methyl Nucleotide Prodrugs for the Treatment of HCV Infection: From Discovery to the Clinic

Epigenetics: HDACs and Beyond

Benzimidazole and Imidazole Inhibitors of Histone Deacetylases: Synthesis and Biological Activity

Design & Development of Novel Classes of HDAC Inhibitors for the Treatment of Immune-Inflammatory Diseases & Cancer

The Chemical Biology of Histone Methyl Transferases