6th Winter Conference

Medicinal and Bioorganic Chemistry

23 - 28 January 2005

  • Conference Agenda

    Saturday January 22, 2005
    1:00 pm to 5:00 pm Registration Registration packets may be picked up from 1:00 - 6:00 pm, at the Conference Registration desk located on the Ballroom level.
    Sunday, January 23, 2005
    1:00 pm to 5:00 pm Registration
    5:00 – 8:00 pm Opening Session - Sunshine Peak/Mt.Werner
      Michael Van Nieuwenhze, University of California – Program Chair

    Organic Synthesis in Non-classical Media

      Paul Grieco, Montana State University Organic Synthesis in Water and Other Polar Media: An Overview
      Hartmut Kolb, The Scripps Research Institute 'In Situ' Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
      Shu Kobayashi, Tokyo University Lewis Acid Catalysis in Aqueous Media
    Monday, January 24, 2005  
    7:00 am Continental Breakfast - Prefunction Area
    8:00-11.00 am Morning Session - Sunshine Peak/Mr. Werner
      Bryan Norman, Eli Lilly & Company – Program Chair

    General Oral Session

    4:00-8:00 pm Evening Session - Sunshine Peak/Mr. Werner
      Lester Mitscher, University of Kansas – Program Chair Sponsored by Celgene

    Blockbuster Drug Symposium

      Andy Bell, Pfizer Global Research & Development The Viagra Story
      Dale Kempf, Abbott Laboratories The Kaletra-Ritonavir Story
      David Wustrow, Pfizer Global R&D The Neurontin Story
    4:00 - 8:00 pm Evening Session - Sunshine Peak/Mt. Werner
      Victor Snieckus, Queen's University - Program Chair

    Cascade Chemistry

      Victor Sniekcus, Queen's University Cascade Chemistry Reactions: An Overview
      Richard Heck Cobalt and Palladium Reagents in Organic Synthesis: The Discovery and the Early Years
      Masahiro Miura, Osaka University Transition Metal Catalyzed Sequential Coupling via C-H Bond Cleavage
      Tom Kieboom, Leiden University Concepts of Nature in Organic Synthesis: Cascade Catalysis and Multistep Conversions in Concert
      Ei-ichi Negishi, Purdue University Tandem and Cascade Carbon-Carbon Bond-Forming Processes Catalyzed by Pd and Zr Complexes
    Tuesday, January 25, 2005  
    7:00 am Continental Breakfast - Prefunction Area
    8:00 - 11:00 am Morning Session - Sunshine Peak/Mt. Werner
      Tony Barrett, Imperial College - Program Chair

    Solid-supported Reagents

      David Bergbrieter, Texas A&M University Soluble Polymers as Easily Separable Supports in Synthesis and Catalysis
      Paul Hanson, University of Kansas ROM-Polymerization Strategies for Facilitated Synthesis
      Steve Ley, Cambridge University Development of New Methods for Organic Synthesis
      John Parlow, Pfizer Global Research & Development Polymer-Assisted Solution-Phase (PASP) Chemical Library Synthesis and its Application on the Tissue Factor VIIa Projects
    4:00 -6:00 pm Bryan Norman, Eli Lilly & Company - Program Chair

    Poster Session - Storm Peak

    11:00 pm - 12:30 am Hockey Game - Howelson Arena
    Wednesday, January 26 2005  
    7:00 am Continental Breakfast - Prefunction Arena
    8:00 - 11:00 am Morning Session - Sunshine Peak/Mt. Werner
      Dennis Dean, Merck Research Labs - Program Chair

    General Oral Papers I

      Bryan Norman, Eli lilly & Company Benzopyrans are selective ERbagonists for use in the treatment of prostatic diseases
      Wayne Brouillette, University of Alabama at Birmingham Design and development of low toxicity UAB-rexinoids for breast cancer chemoprevention
      Robert Meissner, Merck Research Laboratories In vitro and In vivo of a ketone-containing avb3 integrin antagonist for the treatment for osteoporosis
      William Kinney, Johnson & Johnson Computational and pharmacokinetic studies directed at understanding the differences in oral bioavailability seen between closely related aVb3integrin antagonists
      Robert Fecik, University of Minnesota Synthesis of immunomodulatory macrolides for cystic fibrosis
      Katherina Leftheris, Bristol Myers Squibb Progression of a novel class of orally active p38 map kinase inhibitors
      Axrel Neffe, University of Cantebury Synthesis and modelling studies of peptidomimetic aldehydes related to a cataract preventing calpain inhibitor
      Shawn Stachel, Merck Research Laboratories Structure-based design of a series of potent and selective cell permeable inhibitors of humanb-secretase
    12:00 pm Mountain Lunch & Group Photo - Bashor Picnic Area
    2:00 pm NASTAR Race
    6:00 pm Keynote Address - Storm Peak
      Dr Chris Lipinksi, Pfizer Global Research & Development- Program Chair

    Chemistry Quality and the Medicinal Chemistry - Biology Interface

    7:00 pm Banquet & Entertainment - Grand Ballroom
    Thursday, January 27, 2005  
    7:00 am Morning Session - Sunshine PeaKk/Mt. Werner
    8:00 - 11:45 am Dan Flynn, Deciphera Pharmaceuticals - Program Chair

    Protein Conformational Plasticity in Drug Design

      Dan Erianson, Sunesis Inc Drug Discovery at Adaptive Signaling Interfaces
      Betsy Goldsmith, University of Texas Southwestern Medical Center, Dallas Binding Sites and Conformational Changes in Protein Kinases
      Tim Willson, GlaxoSmithKline Exploiting Plasticity in Nuclear Receptor Drug Discovery
      Steven LaPlante, Boehringer Ingelheim Exploiting ligand and receptor adaptability in antiviral drug design
    5:00 - 8:00 pm Evening Session - Sunshine Peak/ Mt. Werner
      Peter Toogood, Pfizer - Program Chair

    Small Molecule Modulation of Protein-Protein Interactions

      Dale Boger, The Scripps Research Institute Targeting Protein-Protein and Protein-DNA Interaction using Solution Phase Combinatorial Chemistry
      Lance Stewart, deCODE Genetics Inc The Poisoning of Human Topoisomerase I by Structurally Diverse Anticancer Compounds and Various Insults to DNA
      Jim Stewart, Sunesis Inc Challenges for Drug Discovery at Protein/Protein Interfaces
      David Rees, Astex Technology Ltd Starting Small and Strong: Fragment Based Drug Discovery
    Friday, January 28, 2005  
    7:00 am Continental Breakfast - Prefunction Area
    8:00 - 11:00 am Morning Session - Sunshine Peak/Mt. Werner
      Philippe Nantermet, Merck Research Laboratories - Program Chair

    General Oral Papers II

      Neville Anthony, Merck Research Laboratories Development of a Potent HIV-1 Integrase Inhibitor with a Unique Resistance Profile
      Charles Didier, Imperial College Double Oxidation of Tryptophanes: Synthesis of the Potent Anthelmintic Pyrrolobenzoxazine CJ-126621
      Theresa Williams, Merck Research Laboratories Calcitonin gene-related peptide antagonists
      Robb Webb, Arena Pharmaceuticals APD 356, A Potent and Selective 5HT2C Agonist is a Potential New Treatment for Obesity
      Birgit Masjost, Roche Diagnostics Structure-based Optimization of Novel Azepane Derivatives as PKB Selective Inhibitors
      Thomas Ruckle, Serono Pharmaceuticals Research Institute Idenfitication and Development of Potent and Selective P13Ká»· Inhibitors
      Kirk Stevens, GloxoSmithKline Unusual Heterocycle Synthesis: Routes to Pyrazolo[1,5-a]Pyridine Compounds as P38 Kinase Inhibitors
    11:00 am Meeting Closes

    Event Sponsors

  • acspublic_sponsor
  • bentham_sponsor
  • celgene_sponsor
  • ilea
  • lilly_sponsor
  • merck_sponsor
  • thieme_sponsor
  • wyeth_sponsor