4th Winter Conference

Medicinal and Bioorganic Chemistry

28 Jan - 2 February 2001

  • Conference Agenda

    Sunday January 28, 2001
    1:00 pm to 5:00 pm Registration Registration packets may be picked up from 1:00 - 6:00 pm, at the Conference Registration desk located on the Ballroom level.
    4:00 to 7:00 pm Welcome Reception and Super Bowl Party
    7:00 pm Victor Snieckus, Queen’s University, Chair

    Symposia Topic 1: Modern Heterocyclic Construction

      Amir Hoveyda, Boston College "Catalytic Enantioselective and Practical Olefin Metathesis Reactions"
      Jin K. Cha, University of Alabama "New Synthetic Methods for Bioactive Heterocycles"
      P. Andrew Evans, University of Delaware "New Organometalice Mediated Cross-Coupling Reactions for the Construction of Complex Biologically Important Natural Products."
    Monday, January 29, 2001  
    8:00-11.00 am Victor Snieckus,Queen's University – Session Chair

    Symposia Topic 1: Modern Heterocyclic Construction

      Ron Grigg, University of Leeds "Catalytic Cascade Reactions: Routes to Potentially Bio-active Complex Heterocycles"
      David J. Hart, Ohio State University "New Wrinkles on Old Reactions in Heterocyclic Chemistry: Applications to Alkaloid Total Synthesis"
      Victor Snieckus, Queen's University "Constructing Substituted Heterocycles: Comparing Directed ortho Metalation with Other Selected Methodologies"
      Al Padwa, Emory University "Cascade Processes for Heterocyclic Synthesis"
    4:00 - 5:00 pm Storm Peak

    Poster Session I

    5:00 - 8:00 pm Bryan H. Norman, Eli Lilly and Company, Chair

    Symposia Topic 2: Target-Driven Approaches to Anticancer Agents

      Homer Pearce, Eli Lilly and Company "Evolving Molecular Targets for Anticancer Drug Discovery"
      Peter L. Toogood, Pfizer Global R&D "Inhibition of Cyclin Dependent Kinases as an Approach to Cancer Therapy"
      Louis Lombardo, Bristol-Myers Squibb "The Discovery & Preclinical Development of Benzodiazepine Farnsey Itransferase Inhibitors"
      Peter Traxler, Novartis Pharma. Ltd. "Tyrosine kinase inhibitors-from rational design to clinical trials"
    Tuesday, January 30, 2001  
    8:00 - 11:00 am David Lau, Amgen Inc., Chair

    Symposia Topic 3: Pharmacokinetics for Medicinal Chemists

      David Lau, Amgen Inc. "Basic Pharmacokinetics Concepts for Medicinal Chemists in Drug Discovery Support"
      Gondi Kumar, Amgen Inc. "Metabolism Issues for Small Molecule Drug Discovery and Development"
    5:00 - 7:30 pm Daniel Flynn, Millennium Pharmaceuticals, Inc., Chair

    Symposia Topic 4: Recent Advances in the Structural Biology of Seven Transmembrane Receptors

      Thue Schwartz, University of Copenhagen "State of the 7TMG-protein union – lessons from metal-ion site engineering and fusion proteins"
      Dale Mierke, Brown University "Peptide Hormone Binding to GPCR Receptors: Structural Characterization via NMR Techniques"
      Oren Becker, Bio Information Technologies "Modeling the 3D Structure of G-Protein Coupled Receptors from Primary Sequence"
    Wednesday, January 31, 2001  
    8:00 - 11:00 am Mike VanNieuwenhze, Chair

    General Papers I

    11:30 am Mountain Lunch at Buddy's Run, followed by group photo
    2:00 pm NASTAR Race - NASTAR Race Course
    5:30 pm Dale Boger, Scripps Research Institute "Vancomycin, Teicoplanin, and Ramoplanin: Synthetic & Mechanistic Studies"

    Keynote Address

    Thursday, February 1, 2001  
    8:00 - 11:00 am Lawrence G. Hamann, Bristol-Myers Squibb, Chair

    Symposia Topic 5: Nuclear Hormone Receptors

      A Brian Jones, Merck Research Laboratories "New PPAR Modulators: Diabetes and Beyond"
      Marcus F. Boehm, Ligand Pharm., Inc. "Rexinoid Receptor Signalling Pathways as Targets for Drug Development"
      Timothy M. Willson, Glaxo-Wellcome R&D "Metabolic Regulation through Orphan Nuclear Receptors"
    4:00 - 5:00 pm Storm Peak

    Poster Sessions II

    5:00 pm – 7:30 pm Lawrence G. Hamann, Bristol-Myers Squibb, Chair

    Symposia Topic 5: Nuclear Hormone Receptors

      Jean-Marie Wurtz, IGBMC "Ligand Specificity in RXR, RAR and VDR"
      John A. Katzenellenbogen, University of Illinois "Novel Ligands for Estrogen Receptor Alpha and Beta"
      Donald P. McDonnell, Duke Univ. Medical Center "Nuclear Receptor-Cofactor Interactions as Targets for New Drug Discovery"
    Friday, February 2, 2001  
    8:00 - 12:00 pm Anthony G. M. Barrett, Imperial College, Chair

    Symposia Topic 6: Alkene Metathesis

      Siegfried Blechert, Technische Universitat Berlin "Sequential Olefin Metathesis—Applications in Natural Product Synthesis"
      Anthony G.M. Barrett, Imperial College "Alkene Metathesis: Applications from Small Moleculels to ROMPGELs"
      Robert Grubbs, California Inst. of Technology "The Use of Ruthenium Carbenes in Synthesis"
    12:00 pm Friday noon conference adjournment


    Steamboat Springs Conference, January 2001 Group Photo