14th Winter Conference – Provisional
on Medicinal & Bioorganic Chemistry

January 27th - 31st 2019

Steamboat Springs Resort, Colorado

Agenda

Sunday, January 27th 2019

Drug Hunting

Program Chair: Dr Daniel Flynn, Deciphera Pharmaceuticals

5.00 pm
Dr Josh Belinker LOXO (Drug Hunter Award)

TRK Inhibitor LOXO-101 and back up LOXO-195

Dr Petr Vachal Merck

The Invention of MK-8262, a CETP Inhibitor Backup to Anacetrapib (with best in class properties)

Dr Kevin Freeman-Cook Pfizer

Targeting the Cell Cycle for the Treatment of Cancer

Networking Session

Welcome Reception

Monday, January 28th 2019

Immuno-oncology

Program Chair: Dr Wes Trotter, Merck

Dr Wes Trotter Merck

Small Molecule Targets in Immuno-Oncology

Dr Jared Cumming Merck

Novel STING Agonists for Immuno-oncology

Dr Paul Scola BMS

Discovery of a Macrocyclic Peptide Inhibitor of Programmed Death-Ligand 1 (PD-L1)

Dr Cynthia Parrish GSK

Targeting the Adenosine Pathway with Non-Nucleoside Inhibitors of CD73

Structural and in-Silico Chemistry

Program Chair: Dr Georgia McGaughey, Vertex

Dr Meihua Tu Pfizer

The Role of Water Molecule in Ketohexokinase Inhibitor Design

Professor Tudor Oprea

Fundamentals of Al-driven Drug Discovery

Dr Clara Christ Bayer

Five years of Binding Free Energy Calculations at Bayer: Impact and Future Directions

Dr Ed Sherer Merck

Impact of Computational Chemistry Post Candidate Selection and Translating Lessons Learned back into Discovery

Tuesday, January 29th 2019

Chemical Biology for Drug Discovery

Program Chair: Dr Paola Castaldi, AstraZeneca

Professor Laura Kiessling MIT

Glycans in Health and Disease

Professor Christina Woo Harvard

Mapping Binding Site Hotspots in the Global Proteome by Photo-affinity Labeling Mass Spectrometry

Dr Tim Rasmusson AstraZeneca

Chemical Degraders for Target Validation: Revealing Biology on the Oncogenic Transcription Factor BCL6

Dr Andy Phillips C4 Therapeutics

Targeted Protein Degradation

Pain

Program Chair: Dr Sarah Skerratt, Vertex

Dr Sarah Skerratt Vertex

Overview of Current Therapies for the treatment of Pain

Dr Mark Layton Merck

Nav 1.7 Blockers

Professor Laura Bohn Scripps

Harnessing Opioid Receptor Signaling to Improve Pain Therapeutics

Dr Brendan Crowley Merck

CGRP Antagonists for Migraine

Dr Leena Otsomaa Orion

TRPA1: A Pain Target or a Painful Target?

Wednesday, January 30th 2019

Recent Advances in Targeting Autophagy

Program Chair: Professor Jay Debnath (UCSF)

Professor Jay Debnath UCSF

Overview of Approaches to Targeting Autophagy in Cancer, Neurodegenerative Diseases and other Indications

Professor Kevan Shokat UCSF

Targeting the Autophagy initiating Kinase ULK1

Professor Ravi Amaravadi University of Pennsylvania

Advances in Targeting Lysozomotropic Agents

Advances in Synthesis and Medicinal Chemistry

Program Chair: Professor Darren Dixon, University of Oxford

Please submit an abstract for consideration

See the Submissions Tab under Registration above

Dr Dominic Reynolds H3 Biomedicine

Complex Natural Product Derivative Synthesis

Thursday, January 31st 2019

Photoredox Catalysis

Program Chair: Dr Dan DiRocco, Merck

Dr Dani Schultz Merck

Recent Advances in the Remote Functionalization of Aliphatic C-H Bonds via Decatungstate Photocatalysis

Dr Thomas Knauber Pfizer

Enablement of Photoredox Csp2-Csp3 Cross Coupling Reactions

Dr Kaid Harper Abbvie

Scaling Catalytic Photochemistry with Lasers

Professor Corey Stephenson University of Michigan

Photoredox Catalysis – An Enabling Platform for Discovery and Development

Professor Tomislav Rovis University of Columbia

New Tools for Catalysis

KEY NOTE PRESENTATION

Program Chair: Professor Anthony Barrett, Imperial College

5.00 - 6.00pm
Professor Phil S. Baran The Scripps Research Institute

Translational Chemistry

Networking Session

Poster Session & Pre-Dinner Drinks

Networking Session

Conference Dinner

Media Sponsors