Board of Directors
Founding Board Members (1994): Dan Flynn, Gary Grunewald, Les Mitscher, Mike Rafferty, Vic Snieckus
Current Board of Directors:
Anthony G.M. Barrett
Imperial College, London
Tony Barrett is the Glaxo Professor of Organic Chemistry and the Sir Derek Barton Professor of Synthetic Chemistry at Imperial College in London, England. He was previously on the faculty in Colorado State University and Northwestern University. He has co-authored over 420 publications and over 27 patents on natural product, heterocyclic, organometallic and porphyrazine chemistry, catalysis and cancer medicinal chemistry. He has received numerous awards for his contributions to research from the Royal Society of Chemistry, the American Chemical Society, the Royal Society, Imperial College, the Camille and Henry Dreyfus Foundation, the Japan Society for the Promotion of Science, GSK and the Institute of Applied Catalysis. He is a Fellow of the Royal Society and the Academy of Medical Sciences.
Daniel L. Flynn
Daniel L. Flynn, PhD is Founder and Chief Scientific Officer of Deciphera Pharmaceuticals, a company he founded in 2003. He received his B.S. in Pharmacy from the University of Kansas in 1977, and then stayed at KU to receive his PhD in medicinal chemistry in 1981 under the mentorship of Prof. Les Mitscher. After completing a post-doctorate in synthetic organic chemistry at Indiana University with Paul Grieco, he joined Warner-Lambert/Parke Davis Pharmaceuticals in Ann Arbor, Michigan, in 1983. In 1988, he moved to Searle Pharmaceuticals in Skokie, IL and later St. Louis, MO. In his ten year period with Searle, he worked with teams that brought five compounds into development, and advanced 3 drugs into clinical trials, including xemilofiban and orbofiban. He also led a technology team to develop a platform in combinatorial chemistry now known as “phase-trafficking” synthesis. In 1998, Dan joined Amgen, Inc in Thousand Oaks, CA, as Director of Medicinal Chemistry. In 2000, he moved to Cambridge, MA, as Senior Director of Chemistry with Millennium Pharmaceuticals. Dan is an Adjunct Professor of Medicinal Chemistry at the University of Kansas-Lawrence and has served as the National Chair for the Division of Medicinal Chemistry of the American Chemical Society. Dan was inducted as an American Chemical Society Fellow in 2013. Additionally, he co-founded the Medicinal & Bioorganic Chemistry Foundation in 1995, whose main charter has been the sponsorship and organization of the perennial Steamboat Springs conference series, the Winter Conference on Medicinal and Bioorganic Chemistry. Dan has authored or co-authored over 100 publications in peer-reviewed journals and has been named an inventor on over 70 patents during his career.
His present research passion at Deciphera is in the area of small molecule kinase modulation through control of kinase conformational shape. This platform, called switch control inhibition, has been utilized at Deciphera to produce multiple drugs in development. Deciphera’s research in oncology has focused on tumor driver mutations, overcoming treatment-emergent drug resistance, cancer immunotherapy, and the tumor microenvironment. Deciphera’s clinical stage drug pipeline includes DCC-2618, rebastinib, and DCC-3014, which are currently in clinical evaluation.
Neil K. Garg
Neil Garg received a B.S. in Chemistry from New York University where he did undergraduate research with Professor Marc Walters. He obtained his Ph.D. in 2005 from Caltech studying under the direction of Professor Brian Stoltz. Garg then joined Professor Larry Overman’s laboratory at the University of California, Irvine as an NIH Postdoctoral Scholar. He joined the faculty at UCLA in 2007 and rose to the rank of Full Professor in 2013. Garg’s laboratory develops synthetic strategies and methodologies that enable the synthesis of complex bioactive molecules. His recent researchrelated honors include a Guggenheim Fellowship, the Thieme–IUPAC Prize, the Royal Society of Chemistry’s Merck Award, and the Elias J. Corey Award. Garg also cherishes the opportunity to teach at the graduate and undergraduate levels. He has received several recognitions for his educational contributions, including the Carnegie Foundation for the Advancement of Teaching’s California’s Professor of the Year Award, and is currently one of three nationwide Finalists for the Robert Foster Cherry Award.
Jnana Therapeutics, 2017
Lyn Jones completed PhD studies in synthetic organic chemistry at the University of Nottingham, before starting his post-doctorate research at The Scripps Research Institute, California in the area of chemical biology. In 2001, he joined Pfizer in Sandwich, UK as a medicinal chemistry team leader, and in 2011 he transferred to Cambridge, MA to become head of Rare Disease Chemistry and to lead the Chemical Biology Group. In 2017, he joined Jnana Therapeutics in Boston (Vice President, Chemical Biology). He is an author or inventor on over 100 publications and patents, a fellow of the Royal Society of Chemistry and the Royal Society of Biology, and he is an elected member of the Chemistry Biology Interface Division Council of the RSC.
Merck, Sharp & Dohme (MSD), Kenilworth, NJ, USA, 2017
Shane W. Krska serves as Senior Principal Scientist in the High-Throughput Experimentation and Lead Discovery Capabilities group in Merck Sharp & Dohme (MSD) Research Laboratories in Kenilworth, NJ. His research at MSD has focused on applications of catalysis to solve challenging problems in drug synthesis spanning from drug discovery to late stage manufacturing process development. He has co-authored more than 50 publications and numerous patent applications in the areas of asymmetric hydrogenation, cross-coupling and C-H functionalization catalysis and their use in pharmaceutical synthesis. Professional honors he has received include being named an ACS Young Industrial Investigator, as well as a co-recipient of the R&D Council of N.J. Thomas Alva Edison Patent Award, the EPA Presidential Green Chemistry award and the Catalysis Society of Metropolitan NY Excellence in Catalysis Award.
Matthew M. Hayward
Pfizer Global R&D, 2013
Chief Financial Officer Elect
Matt obtained his BA from Connecticut College in 1989. During these formative years he worked in the labs of Dr. Bruce Branchini preparing novel analogues of firefly Luciferin. Inspired by his work there he continued his studies at Yale University, obtaining his Ph.D. under Prof. Alana Schepartz in 1995. At Yale Matt worked on several projects at the biology-chemistry interface. Following that, Matt joined the labs of Prof. Yoshito Kishi at Harvard as an NIH postdoctoral fellow. There he worked on and completed the first synthesis of Spongistatin A with fellow co-workers in the Kishi labs. He joined Pfizer in Groton in 1997. Since then he has been a medicinal chemist in the antibacterial, oncology, immunology, inflammation and neuroscience groups. He is currently working in the Discovery Sciences group in Groton, working on platform approaches that address medicinal chemistry issues that span multiple therapeutic areas. Matt’s research interests include structure based drug design and kinase medicinal chemistry.
Philippe G. Nantermet, PhD
Merck & Co., Inc., Kenilworth, NJ USA
Following training with Prof M.T. Crimmins at UNC Chapel Hill and Prof KC Nicolaou at SCRIPPS, Philippe joined the pharmaceutical industry in 1994. Philippe is recognized as Drug Discovery Leader with a broad background in medicinal chemistry, in the areas of neurodegeneration, pain, HIV, arthritis, and cardiovascular research. His diverse team leadership experience spans: Hit Identification, Lead Identification, Lead Optimization, and Preclinical Development to Phase I Testing. He is experienced in program strategy and development, and leveraging new technologies such as parallel medicinal chemistry to accelerate drug design and synthesis. He is experienced in directing CRO operations as support to internal programs, has some expertise in Chemical Biology and screening deck creation/curation. Philippe has authored or co-authored over 40 peer reviewed publications, along with several book chapters, has delivered multiple invited lectures at international conferences, is an inventor on over 30 issued patents, and serves on the board of the Medicinal and Bioorganic Chemistry Foundation.
Bryan H. Norman
Senior Research Advisor and Group Leader in Discovery Chemistry at Eli Lilly and Company
Chief Financial Officer
He received his Ph.D. at Emory University and was an NIH Postdoctoral Fellow at Penn State University. After 3 years at Monstanto/Searle, Bryan joined Lilly in 1993, where he has led multiple drug discovery efforts through the years, many of which culminated in clinical candidates for endocrine and pain indications. Bryan has served on the Board of Directors of the Medicinal and Bioorganic Chemistry Foundation since 1998, currently as Treasurer, and he has also served on the Editorial Board of Burger’s Medicinal Chemistry. He has published over 40 papers and given many invited lectures at scientific conferences and universities. His current research interests are focused on the discovery of novel analgesic agents for use in chronic pain.
Victor Algirdas Snieckus
Queens University, 1994
Victor Algirdas Snieckus was born in Kaunas, Lithuania and spent his childhood in Germany during World War II. Training: U. of Alberta (B.Sc.), strongly influenced by the iconoclastic teacher, Rube Sandin; U. California, Berkeley (M.Sc.), appreciation of physical organic chemistry under D.S. Noyce; U. Oregon (Ph.D.), discovering his passion for organic synthesis under the excellent mentor, Virgil Boekelheide; National Research Council, Ottawa, postdoctoral tenure with the ardent Ted Edwards. Appointments: U. of Waterloo, Assistant Professor, 1966; Monsanto/NRC Industrial Research Chair, 1992-1998; Queen’s University, 1998-2009, inaugural Bader Chair in Organic Chemistry. Selective awards: A.C. Cope Scholar (2001, one of 4 Canadians), Order of the Grand Duke Gediminas (2002, from the President of Lithuania), Arfedson-Schlenk (2003, Geselschaft Deutscher Chemiker), Bernard Belleau (2005, Canadian Society for Chemistry), GivaudanKarrer Medal (2008, U. Zurich), Honoris causa (2009, Technical U. Tallinn, Estonia), Global Lithuanian Leader (2012). Research: The Snieckus group has contributed to the development and application of the directed ortho metalation reaction (DoM) and used it as a conceptual platform for discovery of new efficient methods for the regioselective synthesis of polysubstituted aromatics and heteroaromatics. The directed remote metalation (DreM) reaction and DoM – linked transition metal catalyzed cross coupling (especially Suzuki-Miyaura) were first uncovered in his laboratories. These have found broad application in agrochemical and pharmaceutical industry, e.g. fungicide TAKE-ALL (Monsanto), anti-AIDS Sustiva, anti-inflammatory Losartan (Bristol-Myers Squibb).
He continues fundamental research as Bader Chair Emeritus as well as Director of Snieckus Innovations, an institute for synthesis of small molecules for the pharmaceutical and agrochemical industries. He still plays hockey and wishes he had not given up the clarinet.
Antonia F. Stepan graduated from the ETH Zurich and received her Ph.D. with Professor Steven V. Ley. Following postdoctoral research with Professor K. C. Nicolaou, Antonia joined Pfizer in 2008. She served as a chemistry and research project leader on discovery programs and advanced drug candidates to clinical candidate nomination and beyond. In 2017, Antonia joined Boehringer Ingelheim as a project leader. Antonia is passionate about discovering treatments for neurological and immunological disorders, as well as utilizing novel technologies (e.g., C−H functionalization reactions, sp3-rich fragments) in medicinal chemistry. She was recognized as an ACS “Young Investigator in Medicinal Chemistry” in 2015.
Indiana University, 2008
Michael VanNieuwenhze received his B.A. degree from Kalamazoo College in 1984 and his M.S. from Yale University in 1988. He received his Ph.D. from Indiana University in 1992 where he developed methods for the de novo synthesis of carbohydrates, designed reagents for asymmetric allyl- and crotylmetal addition reactions, and studied fragment assembly aldol reactions for use in the synthesis of complex natural products. Professor VanNieuwenhze conducted his postdoctoral research at The Scripps Research Institute in La Jolla, California where he studied transition-metal catalyzed asymmetric oxidation reactions while working in the laboratories of Professor K. Barry Sharpless (Nobel Laureate, 2001). In 1994, Professor VanNieuwenhze accepted a position in Discovery Chemistry Research at Eli Lilly and Company in Indianapolis. In 2002, he accepted a faculty position at the University of California, San Diego and in 2007, he returned to the Department of Chemistry at Indiana University. His research is characterized by the use of chemistry to study problems of significant biological interest. A major component of his current research program is focused on the study and development of novel antibacterial agents and the development and utilization of methods for imaging the spatial and temporal dynamics of peptidoglycan biosynthesis.
Senior Distinguished Board Advisors:
Dr Michael Rafferty
Deciphera Pharmaceuticals, 1994-2013